Molecular BiologybioRxivPreprint
Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failure
Siavash Mansouri, Inga Hemmerling, Golnaz Hesami…·Soni Savai Pullamsetti
This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.
DOI 10.1101/2024.07.30.605744