Gregory L Dignon

Palindrome Presence, Location, and Structural Context Are Predictive of RNA Self-Association

The paper identifies three classes of palindromic regions in RNA based on structural context and availability, and evaluates their self-interaction stability using simulations.

Designed IDPs phase separate and mix or demix according to sequence designed parameters

This study investigates how sequence design parameters influence phase separation and mixing behavior of intrinsically disordered proteins (IDPs) when mixed.

Analysis and design of disordered polypeptides with optimized sequence patterning properties

This paper introduces a normalized sequence patterning framework for intrinsically disordered proteins and a design algorithm to generate sequences with desired phase separation properties.

Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States

This study shows phosphorylation of SARS-CoV-2 N protein toggles its condensate state between membrane-wetting and engulfment, revealing a regulatory mechanism for viral RNA replication and packaging.

Hydration free energy is a significant predictor of globular protein incorporation into condensates

This study predicts globular protein partitioning into condensates using hydration free energy, showing strong correlation with partition coefficients and highlighting limitations of the approach.

Controlled and orthogonal partitioning of large particles into biomolecular condensates

This study demonstrates that large particles can be controlled and orthogonally partitioned into biomolecular condensates through strong particle-condensate interactions, using polymer nanoparticles with tailored surface chemistries.