Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma
Yongrui Hai, Ruizhuo Lin, Weike Liao, Siqing Fu, Renming Fan, Guiquan Ding, Junyan Zhuang, Bingjie Zhang, Yi Liu, Jun-Ke Song, Gaofei Wei
This study shows that inhibiting DHODH promotes NK cell infiltration and activates cGAS-STING and pyroptosis pathways, enhancing anti-tumor immunity in melanoma.
bioRxiv · Mar 20, 2025 · PreprintCancer Biology