Cancer BiologybioRxivPreprint
Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma
Yongrui Hai, Ruizhuo Lin, Weike Liao…·Gaofei Wei
This study shows that inhibiting DHODH promotes NK cell infiltration and activates cGAS-STING and pyroptosis pathways, enhancing anti-tumor immunity in melanoma.
DOI 10.1101/2025.03.20.644471