Structural divergence in protein evolution of a photoreceptor family undetected by AlphaFold is observed by high sensitivity FT-IR spectroscopy
Rosalie L. Dohmen, Gunnar Hoogerwerf, Aihua Xie, Wouter D. Hoff
The paper uses ancestral sequence reconstruction and FTIR spectroscopy to reveal structural divergence in PYP proteins undetected by AlphaFold.
bioRxiv · Aug 6, 2026 · PreprintBiophysics