Structural divergence in protein evolution of a photoreceptor family undetected by AlphaFold is observed by high sensitivity FT-IR spectroscopy
Rosalie L. Dohmen, Gunnar Hoogerwerf, Aihua Xie, Wouter D. Hoff
The paper uses ancestral sequence reconstruction and FTIR spectroscopy to reveal structural divergence in PYP proteins undetected by AlphaFold.