H. Akasaka

cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.

The paper reports the cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens and develops mutants with blue-shifted action spectra.

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

Structure and dynamics of the RF-amide QRFP receptor GPR103

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.

Optimizing Cryo-EM Structural Analysis of Gi-coupling Receptors via Engineered Gt and Nb35 Application

The paper uses engineered G protein eGt with Nb35 to improve cryo-EM structure determination of GPCR-Gi complexes, achieving better map quality and reduced anisotropy.

Cryo-EM structure of the endothelin-1-ETB-Gi complex

The paper reports a cryo-EM structure of the endothelin-1-ETB-Gi complex, revealing structural changes upon G-protein activation and unique binding characteristics.