BiochemistrybioRxiv
Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism
W. Shihoya, H. Akasaka, P. A. Jordan…·O. Nureki
The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.