H. Atze

Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

The paper uses heavy isotope labeling and mass spectrometry to show that YcbB and PBPs have similar roles in peptidoglycan polymerization but YcbB mediates beta-lactam resistance through unique cross-linking mechanisms.

Tryptophan fluorescence quenching in β-lactam-interacting proteins is modulated by the structure of intermediates and final products of the acylation reaction

This study shows that fluorescence quenching in β-lactam-interacting proteins depends on the structure of reaction intermediates and products, not direct Trp-drug interactions.