M. Arthur

Peptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in Escherichia coli

The paper uses mass spectrometry to study the kinetics of Braun lipoprotein (Lpp) tethering to peptidoglycan (PG) and its hydrolysis, revealing dynamic equilibrium between PG-tethered and free Lpp forms.

Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

The paper uses heavy isotope labeling and mass spectrometry to show that YcbB and PBPs have similar roles in peptidoglycan polymerization but YcbB mediates beta-lactam resistance through unique cross-linking mechanisms.

Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

This study identifies endopeptidases essential for peptidoglycan synthesis with different cross-link types and shows their dual specificity and role in bypassing PBPs.

Tryptophan fluorescence quenching in β-lactam-interacting proteins is modulated by the structure of intermediates and final products of the acylation reaction

This study shows that fluorescence quenching in β-lactam-interacting proteins depends on the structure of reaction intermediates and products, not direct Trp-drug interactions.

In vitro and intracellular activity of imipenem combined with tedizolid, rifabutin, and avibactam against Mycobacterium abscessus

This study evaluates the in vitro and intracellular activity of imipenem combined with tedizolid, rifabutin, and avibactam against Mycobacterium abscessus, finding synergistic effects and improved efficacy with certain combinations.