Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma.
P. Webster, J. C. Dawes, H. Dewchand, K. Takacs, B. Iadarola, B. J. Bolt, J. J. Caceres, J. Kaczor, L. Game, T. Adejumo, J. Elliott, K. Naresh, G. Tan, G. Dharmalingam, A. Paccanaro, A. Uren
The paper tracks subclonal mutation frequencies in mouse lymphoma models to identify cancer drivers and demonstrates negative selection of potentially deleterious mutations.
bioRxiv · Jun 29, 2017Cancer Biology