Bet-hedging antimicrobial strategies in macrophage phagosome acidification drive the dynamics of Cryptococcus neoformans intracellular escape mechanisms
Q. Dragotakes, E. Jacobs, L. S. Ramirez, O. I. Yoon, C. Perez-Stable, H. Eden, J. Pagnotta, R. Vij, A. Bergman, F. D'Alessio, A. Casadevall
This study identifies that stochastic phagosomal acidification and oxidative stress drive stochastic Dragotcytosis in Cryptococcus neoformans, enabling fungal escape from macrophages.
bioRxiv · Nov 29, 2021Microbiology