Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2
S. M. Fred, L. Laukkanen, C. Brunello, L. Vesa, H. Goos, I. Cardon, R. Moliner, T. Maritzen, M. Varjosalo, P. C. Casarotto, E. Castren
This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.
bioRxiv · Sep 30, 2019Pharmacology & Toxicology