E. Castren

BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors

This study investigates how glucocorticoids and TRKB signaling interact to modulate neuronal plasticity, finding that glucocorticoids promote TRKB dimerization and interact with TRKB to influence its activity and behavioral effects.

Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21

This study shows that C21, an AT2R agonist, increases TRKB surface levels and enhances BDNF's effect on pTRKB in neurons, reducing freezing time in mice in a BDNF-dependent manner without affecting anxiety.

Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants in vitro

This study tests antidepressants and antipsychotics against SARS-CoV-2 pseudoviruses and finds fluoxetine inhibits infection, including against variants with spike mutations.

Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats

This study shows that inhibiting nitric oxide synthase reduces stress-induced DNMT3b expression in rat hippocampus, suggesting a role for NO in stress-related epigenetic changes.

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.

Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN

This study shows losartan has antidepressant-like effects via AGTR2-mediated TRKB transactivation and FYN recruitment in brain regions.

Elastase-2 knockout mice display anxiogenic- and antidepressant-like phenotype: putative role for BDNF metabolism in prefrontal cortex

This study shows that Elastase-2 knockout mice exhibit anxiogenic and antidepressant-like behaviors, possibly due to increased BDNF levels in the prefrontal cortex.

Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania

This study shows that NOS2 knockout mice exhibit increased barbering behavior and repetitive movements, linked to altered NMDA receptor levels and neuronal morphology, suggesting a role for NOS2 in striatal motor regulation.