H. Haller

Urokinase receptor associates with TLR4 interactome to promote LPS response

This study shows uPAR interacts with TLR4 to enhance LPS response, leading to increased inflammation and worse outcomes in sepsis.

Notch and TLR signaling coordinate monocyte cell fate and inflammation

This study shows that Notch2 and TLR7-Myd88 pathways regulate Ly6Chi monocyte differentiation and inflammation in mice.

Heparanase-2 protects from endothelial injury by inhibiting TLR4 signaling

This study shows that HPSE2 protects endothelial cells from LPS-induced injury by inhibiting TLR4 signaling and reducing cytokine expression.

Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice

This study shows calcium dobesilate inhibits VEGF signaling by blocking heparan sulfate binding, reducing vascular complications in diabetic mice.