Author

M. Lochner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Preti· 3 shared B. Frenguelli· 2 shared C. A. Reynolds· 2 shared D. Ross-Kaschitza· 2 shared G. Deganutti· 2 shared G. Ladds· 2 shared H. Abriel· 2 shared J.-S. Rougier· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPharmacology & Toxicology

B. Preti

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Silicon-rhodamine functionalized evocalcet probes (EvoSiR) potently and selectively label calcium sensing receptors (CaSR) in vitro, in vivo and ex vivo

D. Batora, J. P. Fischer, R. M. Kaderli, M. Varga, M. Lochner, J. Gertsch

This paper develops fluorescent probes EvoSiR4 and EvoSiR6 that potently and specifically label CaSR in vitro, in vivo, and ex vivo, outperforming evocalcet and its linker conjugate.

bioRxiv · Feb 22, 2024 · PreprintPharmacology & Toxicology

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

B. Ekundayo, P. Arullampalam, C. Gerber, A.-F. Haemmerli, S. Guichard, M. Boukenna, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Stahlberg, H. Abriel, D. Ni

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

bioRxiv · Jan 22, 2024Biochemistry

Functional design of bacterial superoxide:quinone oxidoreductase

C. von Ballmoos, A. Abou-Hamdan, R. Mahler, P. Grossenbacher, O. Biner, D. Sjöstrand, M. Lochner, M. Högbom

The paper confirms quinone and superoxide as substrates for CybB, showing quinone binding accelerates the reaction and determines the midpoint potential of the two b hemes.

bioRxiv · Dec 23, 2021Biochemistry

Species-specific effects of cation channel TRPM4 small-molecule inhibitors

P. Arullampalam, B. Preti, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Abriel

This study compares the effects of TRPM4 inhibitors on human and mouse TRPM4 channels, revealing species-specific responses and highlighting the need for in vivo validation.

bioRxiv · Jun 1, 2021Pharmacology & Toxicology

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

G. Deganutti, K. Barkan, B. Preti, M. Leuenberger, M. Wall, B. Frenguelli, M. Lochner, G. Ladds, C. A. Reynolds

The paper uses molecular dynamics simulations and mutagenesis to study agonist binding to the A1 receptor, identifying new residues and binding modes of CPA-related ligands.

bioRxiv · Oct 22, 2020Pharmacology & Toxicology

Notch and TLR signaling coordinate monocyte cell fate and inflammation

J. Gamrekelashvili, T. Kapanadze, S. Sablotny, C. Ratiu, K. Dastagir, M. Lochner, S. Karbacher, P. Wenzel, A. Sitnow, S. Fleig, T. Sparwasser, U. Kalinke, H. Haller, B. Holzmann, F. Limbourg

This study shows that Notch2 and TLR7-Myd88 pathways regulate Ly6Chi monocyte differentiation and inflammation in mice.

bioRxiv · Apr 28, 2020Immunology

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, , B. Frenguelli

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

bioRxiv · Apr 4, 2020Physiology