Author

H. Herzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. E. Granada· 3 shared A. Kramer· 3 shared A. Zehtabian· 2 shared C. H. Gabriel· 2 shared H. Ewers· 2 shared A. Finzel· 1 shared A. Grudziecki· 1 shared A. Loewer· 1 shared

Activity by Year

2016-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

A. E. Granada

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Circadian period is compensated for repressor protein turnover rates in single cells

C. H. Gabriel, M. H. del Olmo, A. R. Widini, R. Roshanbin, J. Woyde, E. Hamza, N.-N. Gutu, A. Zehtabian, H. Ewers, A. E. Granada, H. Herzel, A. Kramer

The paper investigates how circadian period compensates for fluctuations in repressor protein turnover rates in single cells using fluorescently labeled proteins and mathematical modeling.

bioRxiv · Feb 6, 2024Cell Biology

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping

C. Ector, C. Schmal, J. Didier, S. De Landtsheer, A.-M. Finger, F. Müller-Marquardt, J. Schulte, T. Sauter, U. Keilholz, H. Herzel, A. Kramer, A. E. Granada

This study identifies optimal drug treatment times by analyzing circadian rhythms and drug responses in cancer cells using high-throughput deep phenotyping.

bioRxiv · Nov 30, 2023Cancer Biology

Maintaining and escaping feedback control in hierarchically organised tissue: a case study of the intestinal epithelium

M. M. Fischer, H. Herzel, N. Bluethgen

The paper presents a mathematical model of intestinal epithelium dynamics showing how feedback control maintains homeostasis and enables recovery from perturbations.

bioRxiv · Jun 11, 2021 · PreprintCancer Biology

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

C. H. Gabriel, M. del Olmo, A. Zehtabian, S. Reischl, H. van Dijk, B. Koller, A. Grudziecki, B. U. Maier, H. Ewers, H. Herzel, A. E. Granada, A. Kramer

The paper develops a CRISPR-based method to generate knock-in cells for circadian clock proteins, revealing unexpected nuclear dynamics and rhythmic patterns of CRY1 and PER2.

bioRxiv · Feb 28, 2020Cell Biology

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells

G. Moenke, E. Christiano, A. Finzel, D. Friedrich, H. Herzel, M. Falcke, A. Loewer

The paper studies p53 network dynamics in single cells, showing excitable behavior with tunable activation thresholds and heterogeneity in response due to Wip1 levels.

bioRxiv · Aug 9, 2016Cell Biology