Author

J. Schulte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Henssen· 2 shared A. Bhattacharya· 1 shared A. E. Granada· 1 shared A. Eggert· 1 shared A. Heeren-Hagemann· 1 shared A. Kentsis· 1 shared A. Kramer· 1 shared A. Kung· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

A. Henssen

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Author profile →

5 papers

Recent·Most cited

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping

C. Ector, C. Schmal, J. Didier, S. De Landtsheer, A.-M. Finger, F. Müller-Marquardt, J. Schulte, T. Sauter, U. Keilholz, H. Herzel, A. Kramer, A. E. Granada

This study identifies optimal drug treatment times by analyzing circadian rhythms and drug responses in cancer cells using high-throughput deep phenotyping.

bioRxiv · Nov 30, 2023Cancer Biology

Amplicon structure creates collateral therapeutic vulnerability in cancer

Y. Bei, L. Brame, M. Kirchner, R. Fritsche, S. Kunz, A. Bhattacharya, J. Koeppke, J. Proba, N. Wittstruck, O. Sidorova, R. Chamorro, H. Dorado Garcia, L. Brueckner, R. Xu, M. Giurgiu, , A. Henssen

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

bioRxiv · Sep 8, 2022 · PreprintCancer Biology

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma

B. Decaesteker, A. Louwagie, S. Loontiens, F. De Vloed, J. Roels, S. Vanhauwaert, S. De Brouwer, E. Sanders, G. Denecker, E. D'haene, S. Van Haver, W. Van Loocke, J. Van Dorpe, D. Creytens, N. Van Roy, , F. Speleman

This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.

bioRxiv · Aug 21, 2020 · PreprintCancer Biology

Deep learning detects virus presence in cancer histology

J. N. Kather, J. Schulte, H. I. Grabsch, C. Loeffler, H. S. Muti, J. Dolezal, A. Srisuwananukorn, N. Agrawal, S. Kochanny, S. von Stillfried, P. Boor, T. Yoshikawa, D. Jaeger, C. Trautwein, P. Bankhead, , A. T. Pearson

This paper uses deep learning to detect the presence of HPV and EBV in cancer histology images, achieving high accuracy in predicting virus-associated tumors.

bioRxiv · Jul 5, 2019 · PreprintCancer Biology

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

A. Henssen, C. Reed, E. Jiang, H. D. Garcia, J. von Stebut, I. MacArthur, P. Hundsdoerfer, J. Hyun Kim, E. de Stanchina, Y. Kuwahara, H. Hosoi, N. Ganem, F. Dela Cruz, A. Kung, J. Schulte, , A. Kentsis

This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.

bioRxiv · Aug 25, 2017Cancer Biology