A. Kramer

Circadian Coupling Orchestrates Cell Growth

This study shows that extracellular circadian communication coordinates the circadian clock and cell cycle, and its disruption impairs tissue growth and links circadian disruption to oncogenic processes.

Circadian period is compensated for repressor protein turnover rates in single cells

The paper investigates how circadian period compensates for fluctuations in repressor protein turnover rates in single cells using fluorescently labeled proteins and mathematical modeling.

Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping

This study identifies optimal drug treatment times by analyzing circadian rhythms and drug responses in cancer cells using high-throughput deep phenotyping.

A role for caveolar proteins in regulation of the circadian clock

This study shows that cavin proteins modulate the circadian clock by interacting with PER2 and responding to stimuli like oxidative stress and calcium influx.

Insulin-stimulated adiponectin secretion in pregnancy is mediated by inhibition of adiponectin ubiquitination and degradation and is impaired in obesity

The paper investigates how insulin affects adiponectin secretion in pregnancy and shows that obesity impairs this process through increased ubiquitination and degradation of adiponectin.

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

The paper shows that myeloid clocks are not required for circadian rhythms in cytokine responses or immune cell trafficking after LPS challenge, suggesting systemic cues drive these responses.

A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-like 2, a Microtubule Regulator

This paper evaluates FL2-NPsi, a nanoparticle-encapsulated siRNA targeting FL2, in a rat model of corneal alkaline burn, finding it enhances wound healing without toxicity.

Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

The paper develops a CRISPR-based method to generate knock-in cells for circadian clock proteins, revealing unexpected nuclear dynamics and rhythmic patterns of CRY1 and PER2.

Heritable gene expression variability governs clonal heterogeneity in circadian period

The paper investigates clonal heterogeneity in circadian period by analyzing gene expression patterns across 25 clonal cell populations and identifies heritable and epigenetic factors contributing to period variation.