TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infection
M. J. Tuazon Kels, Z. A. Zumaih, E. Ng, P. Pandey, S. R. Ruuls, H. Korner, T. P. Newsome, G. Chaudhri, G. Karupiah
This study shows TNF deficiency during ECTV infection leads to excessive cytokine production and lung damage, which can be mitigated by STAT3 inhibition.
bioRxiv · Dec 22, 2019Immunology