E. Ng

Sinorhizobium meliloti BR-bodies promote fitness during host colonization

This study shows that BR-bodies in Sinorhizobium meliloti enhance mRNA decay efficiency and symbiotic fitness during host colonization.

The coordination between penicillin-binding protein 1a (PBP1a) and the hydrolytic peptidase DacB determines the integrity of bacterial cell poles

The paper shows that moenomycin inhibits PBP1a2, leading to pole degradation by DacB in Myxococcus xanthus, revealing coordination between PG synthases and hydrolases is critical for cell integrity.

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.

Neuroinvasion of SARS-CoV-2 in human and mouse brain

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

Poxvirus-encoded TNF receptor homolog dampens inflammation and protects the host from uncontrolled lung pathology and death during respiratory infection

This study shows that the ECTV CrmD protein reduces inflammation and protects mice from lethal lung disease during respiratory infection by modulating TNF, IL-6, IL-10, and IFN-γ.

TNF deficiency dysregulates inflammatory cytokine production leading to lung pathology and death during respiratory poxvirus infection

This study shows TNF deficiency during ECTV infection leads to excessive cytokine production and lung damage, which can be mitigated by STAT3 inhibition.

RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation

This study shows that RUNX1-ETO expression in hESC-derived myeloid precursors causes chromatin reprogramming, blocks differentiation, and arrests growth, with effects specific to a sub-population of cells.