The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection
L. T. Mai, S. Swaminathan, T. H. Nguyen, T. Charpentier, H. Loucif, L. Carmona-Perez, A. Lamarre, K. M. Heinonen, J. H. Fritz, S. Stager
This study identifies IRF-5 as essential for maintaining mitochondrial function and oxidative phosphorylation in CD8 T cells during chronic LCMV Cl13 infection, preventing functional exhaustion and cell death.
bioRxiv · Jan 29, 2024 · PreprintImmunology