S. Swaminathan

The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

This study identifies IRF-5 as essential for maintaining mitochondrial function and oxidative phosphorylation in CD8 T cells during chronic LCMV Cl13 infection, preventing functional exhaustion and cell death.

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.

Exponentially decreasing exposure of antigen generates anti-inflammatory T-cell responses

This study shows that reducing antigen exposure exponentially decreases pro-inflammatory T cell responses and promotes regulatory T cells in a mouse model of rheumatoid arthritis.

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

The paper identifies profibrotic monocyte-derived alveolar macrophages and neutrophil recruitment as drivers of lung fibrosis in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

GAUT10 is required for Arabidopsis root cell differentiation and elongation

This study shows GAUT10 is essential for root cell differentiation and elongation in Arabidopsis by affecting cell wall composition and auxin signaling.

Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

The paper identifies conserved T-cell epitopes in SARS-CoV-2 and finds that immune responses against them are subdominant due to low antigen abundance.

Deciphering the role of mucosal immune responses and cervicovaginal microbiome in resistance to HIV infection in HIV-exposed seronegative (HESN) women

This study identifies elevated antiviral cytokines, immunoglobulins, and specific immune cell subsets in HESN women, along with increased bacterial diversity and Gardnerella spp abundance in the cervicovaginal microbiome, suggesting protective mechanisms against HIV.

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

The Oncogenic Function of PLAGL2 is Mediated via Specific Target Genes Through a Wnt-independent Mechanism in Colorectal Cancer

This study identifies PLAGL2 as a key driver of colorectal cancer by promoting proliferation and cell cycle progression through direct target genes IGF2 and ASCL2, independent of Wnt signaling.

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

This study shows that MYC in lymphomas inhibits NK cell maturation by suppressing STAT1/2 and IFN secretion, and restoring NK cells improves survival in lymphoma models.

Transparency in Authors’ Contributions and Responsibilities to Promote Integrity in Scientific Publication

The paper advocates for transparent authorship practices in scientific publishing by recommending standardized authorship criteria, CRediT methodology, ORCID identifiers, and institutional and funding agency support.

Standardising and harmonising research data policy in scholarly publishing

The paper discusses research data policies in scholarly publishing and their impact on data sharing practices among funders and institutions.