The NAD+-dependent deacetylase Sir2 enables evolution of new traits by regulating distinct gene sets in two yeast species, Saccharomyces cerevisiae and Kluyveromyces lactis
K. M. Humphrey, L. Zhu, M. A. Hickman, S. Hasan, H. Maria, T. Liu, L. N. Rusche
This study shows that sirtuin deacetylases regulate distinct gene sets in two yeast species, enabling adaptive responses to low NAD+ stress through species-specific transcriptional rewiring.
bioRxiv · Aug 13, 2019 · PreprintEvolutionary Biology