Author

H. Ooka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Nakamura· 2 shared Y. Chiba· 2 shared M. Wintzer· 1 shared N. Dohmae· 1 shared N. Tsunematsu· 1 shared T. Suzuki· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

R. Nakamura

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2 papers

Recent·Most cited

Diverse Phosphoserine Phosphatases Exhibit Maximum Activity at an Intermediate Binding Affinity in Accord with the Sabatier Principle of Catalysis

Y. Chiba, H. Ooka, M. Wintzer, N. Tsunematsu, T. Suzuki, N. Dohmae, R. Nakamura

This paper shows that phosphoserine phosphatases exhibit maximum activity at an intermediate binding affinity, supporting the Sabatier principle of catalysis when considering both Km and the product release rate constant.

bioRxiv · Mar 10, 2023 · PreprintBiochemistry

Universal Design Principle to Enhance Enzymatic Activity using the Substrate Affinity

H. Ooka, Y. Chiba, R. Nakamura

The paper demonstrates that setting the Michaelis-Menten constant (Km) equal to substrate concentration (S) maximizes enzymatic activity, providing a quantitative guideline for enzyme optimization.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry