N. Dohmae

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Structure of PSI-LHCI from Cyanidium caldarium provides evolutionary insights into conservation and diversity of red-lineage LHCs

The paper determines the structure of PSI-LHCI from Cyanidium caldarium and investigates its evolutionary relationships with other red-lineage LHCs.

Diverse Phosphoserine Phosphatases Exhibit Maximum Activity at an Intermediate Binding Affinity in Accord with the Sabatier Principle of Catalysis

This paper shows that phosphoserine phosphatases exhibit maximum activity at an intermediate binding affinity, supporting the Sabatier principle of catalysis when considering both Km and the product release rate constant.

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120

The paper determines the structure of a monomeric photosystem I core complex with IsiA proteins from Anabaena sp. PCC 7120 under iron deficiency, revealing their role in inhibiting PSI oligomerization.

Lysosomal vesiculophagy terminates STING signalling

This study identifies lysosomal vesiculophagy as a mechanism for STING degradation, preventing sustained type I interferon response.

Structural insights into an evolutionary turning-point of photosystem I from prokaryotes to eukaryotes

The paper presents a cryo-EM structure of tetrameric PSI from Cyanophora paradoxa, revealing structural differences from cyanobacterial PSI that suggest evolutionary changes in PSI organization.

Structural basis for the absence of low-energy chlorophylls responsible for photoprotection from a primitive cyanobacterial PSI

The paper solves the structure of a cyanobacterial PSI lacking low-energy chlorophylls, revealing their absence and functional roles in photoprotection and evolution.

Homeostatic regulation of STING by Golgi-to-ER membrane traffic

This study identifies STING as a cargo of Golgi-to-ER transport and shows that impaired retrograde transport due to COPA syndrome mutations leads to STING activation and autoinflammation.

Assessment of a western blot signal for the Bcnt/Cfdp1, a tentative component of Srcap chromatin remodeling complex; trial to overcome off-target problems

The paper evaluates anti-Bcnt/Cfdp1 antibodies for western blotting, identifies a doublet in mutant mouse cells, and discusses off-target immune reactions.