H. Roelink

Loss of the Heparan Sulfate Proteoglycan Glypican5 facilitates long range Shh signaling.

The paper shows that loss of Glypican5 enhances Shh distribution through the extracellular matrix by reducing sequestering molecules, while Ext1 deficiency impairs Shh secretion.

Sonic Hedgehog is a member of the Hh/DD-peptidase family that spans the eukaryotic and bacterial domains of life.

The paper identifies Sonic Hedgehog (Shh) as a member of the Hh/DD-peptidase family, showing its conserved domains in bacteria and its role in development and signaling.