Dissecting the Thermodynamics of ATP Binding to GroEL One Nucleotide at a Time
T. Walker, H. M. Sun, T. Gunnels, V. Wysocki, A. Laganowsky, H. Rye, D. H. Russell
This paper uses variable-temperature electrospray ionization native mass spectrometry to study the thermodynamics of ATP binding to the GroEL complex, revealing enthalpy-entropy compensation and cooperativity.
bioRxiv · Sep 13, 2022Biophysics