T. Walker

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

This study shows that CGRP impairs load-stimulated proteoglycan production in human chondrocytes by modulating WNT activity, suggesting a new therapeutic target for osteoarthritis.

Pathogenic IgE-fated memory B cell responses retain functional plasticity

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.

Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens

This study shows that sequential switching through IgG1 is not essential for IgE affinity, anaphylaxis, or allergic memory in food allergies.

Global patterns of plant form and function are strongly determined by evolutionary relationships

The paper examines how evolutionary relationships influence plant trait variation, finding that traits like plant height and leaf nitrogen are strongly constrained by phylogeny.

Dissecting the Thermodynamics of ATP Binding to GroEL One Nucleotide at a Time

This paper uses variable-temperature electrospray ionization native mass spectrometry to study the thermodynamics of ATP binding to the GroEL complex, revealing enthalpy-entropy compensation and cooperativity.

Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements

This study reports two high-density Wolbachia strains in Anopheles species, showing independent acquisitions and limited prophage elements, with genomic analysis revealing metabolic completeness and cytoplasmic incompatibility factors.

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

The paper shows that DDR heterogeneity in ovarian cancer predicts patient outcomes and chemotherapy response by analyzing DDR pathway interactions and constructing predictive DDR signatures.

Overabundance of Asaia and Serratia bacteria is associated with deltamethrin insecticide susceptibiltiy in Anopheles coluzzii from Agboville, Cote d'Ivoire

The paper identifies associations between deltamethrin resistance in Anopheles coluzzii and specific bacterial genera, suggesting potential microbial markers for insecticide resistance surveillance.

Evidence for natural hybridisation and novel Wolbachia strain superinfections in the Anopheles gambiae complex from Guinea

This study identifies novel Wolbachia strains and hybridization in Anopheles mosquitoes from Guinea, with higher prevalence in hybrids and a new high-density strain.

Genomic and microscopic evidence of stable high density and maternally inherited Wolbachia infections in Anopheles mosquitoes

The paper identifies high-density, maternally inherited Wolbachia infections in Anopheles mosquitoes using genomic and microscopic evidence, suggesting their potential for biocontrol.

Microbial and autoantibody immunogenic repertoires in TIF1γ autoantibody positive dermatomyositis

This study identifies expanded microbial and autoantigen antibody repertoires in TIF1γ-positive dermatomyositis, revealing viral enrichment and epitope homology with TRIM proteins.

Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

The paper assesses the susceptibility of Anopheles stephensi to Ethiopian Plasmodium vivax and P. falciparum isolates, finding high receptivity and potential for increased malaria transmission in the Horn of Africa.

An assessment of adult mosquito collection techniques for studying species abundance and diversity in Maferinyah, Guinea

The paper compares mosquito collection techniques in Guinea, finding Stealth traps most effective and revealing new species.

The abundance and diversity of West Nile virus mosquito vectors in two Regional Units of Greece during the onset of the 2018 transmission season

The paper examines mosquito vector abundance and diversity for West Nile virus in Greece, finding hybrids and pipiens types prevalent, with WNV detected in Argolida.

Detection of a novel insect specific flavivirus across ecologically diverse populations of Aedes aegypti on the Caribbean Island of Saint Lucia

The paper surveys Aedes aegypti and Ae. albopictus across Saint Lucia, finding a novel insect-specific flavivirus with high prevalence in Ae. aegypti.

A systematic review and meta-analysis of the human blood index of the major African malaria vectors

This study systematically reviews and meta-analyzes the human blood index (HBI) of major African malaria vectors, finding higher HBI in Anopheles gambiae and An. funestus compared to An. arabiensis, with location being a stronger predictor than species.

Whole genome sequencing for predicting clarithromycin resistance in Mycobacterium abscessus

This study uses whole genome sequencing to predict clarithromycin resistance in Mycobacterium abscessus by identifying known and novel resistance-determining mutations.

Assessing the blood-host plasticity and dispersal rate of the malaria vector Anopheles coluzzii

The paper introduces a method to assess blood-host plasticity and dispersal rate of Anopheles coluzzii using blood-meal source detection and molecular analysis.

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

The paper identifies novel Wolbachia strains in multiple Anopheles species from Sub-Saharan Africa and assesses their association with Plasmodium infection.

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific genetic changes associated with immortalisation and malignancy.

This study identifies stage-specific genetic changes in head and neck squamous cell carcinoma progression, highlighting CSMD1 inactivation as a key factor in early carcinogenesis and metastasis.

Diverse novel resident Wolbachia strains in Culicine mosquitoes from Madagascar

The paper identifies diverse novel Wolbachia strains in Culicine mosquitoes from Madagascar and reports Rift Valley fever virus presence in some species.

A quantitative evaluation of MIRU-VNTR typing against whole-genome sequencing for identifying Mycobacterium tuberculosis transmission: A prospective observational cohort study

This study evaluates MIRU-VNTR typing against whole-genome sequencing to identify Mycobacterium tuberculosis transmission, finding low predictive value of MIRU-VNTR and lineage-specific performance.