Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction
H. Sid, T. von Heyl, S. Schleibinger, R. Klinger, L. Heyemelot Nabel, H. K. Vikkula, R. Guabiraba, V. Guillory, R. Scicluna, M. M. Alhussien, B. Boehm, B. Schade, D. Elleder, S. Sives, L. Vervelde, , B. Schusser
This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.
bioRxiv · Nov 1, 2023Immunology