Knockout of αβ but not γδ T cells in chickens is associated with high cytotoxicity and deficiency of regulatory and helper T cells
T. von Heyl, R. Klinger, D. Aumann, C. Zenner, M. Alhussien, A. Schlickenrieder, K. Lengyel, H.-K. Vikkula, T. Mittermair, H. Sid, B. Schusser
This study generates chicken T cell knockout models to investigate their roles, finding that β T cell loss causes severe immunological defects while γδ T cell loss does not.
bioRxiv · Mar 10, 2023Immunology