Author

H. T. Facundo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

P. L. O. Cunha· 3 shared A. M. B. Lucas· 2 shared P. B. Palacio· 2 shared A. B. Chaves Filho· 1 shared A. J. Kowaltowski· 1 shared A. L. N. Varela· 1 shared C. E. B. David· 1 shared G. C. d. F. Soares· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

P. L. O. Cunha

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3 papers

Recent·Most cited

Competitive interaction between ATP and GTP regulates mitochondrial ATP-sensitive potassium channels

P. B. Palacio, G. C. d. F. Soares, G. M. B. Lima, P. L. O. Cunha, A. L. N. Varela, H. T. Facundo

This study investigates how ATP and GTP compete to regulate mitochondrial ATP-sensitive potassium channels using biochemical, pharmacological, and computational methods.

bioRxiv · Jan 24, 2023Pharmacology & Toxicology

Effects of calorie restriction on reactive oxygen species production by mitochondrial reverse electron transport, mitochondrial permeability transition pore, and beta-adrenergic stimulation during cardiac hypertrophy

A. M. B. Lucas, P. B. Palacio, P. L. O. Cunha, H. T. Facundo

This study investigates how calorie restriction affects mitochondrial function, oxidative stress, and beta-adrenergic signaling in cardiac hypertrophy, finding reduced ROS production and improved mitochondrial content but no change in beta-adrenergic insensitivity.

bioRxiv · Feb 2, 2022 · PreprintBiochemistry

Calorie Restriction Maintains Mitochondrial Function and Redox Balance Avoiding Lipidomic Reprogramming during Isoproterenol-Induced Cardiac Hypertrophy

C. E. B. David, A. M. B. Lucas, P. L. O. Cunha, Y. I. P. Viana, M. Y. Yoshinaga, S. Miyamoto, A. B. Chaves Filho, A. J. Kowaltowski, H. T. Facundo

This study shows calorie restriction prevents cardiac hypertrophy-induced lipidomic changes, mitochondrial dysfunction, and oxidative stress in vivo.

bioRxiv · Jul 13, 2021Biochemistry