A. J. Kowaltowski

This paper develops a practical and robust method to assess primary pancreatic islet metabolic fluxes using standard Seahorse equipment, showing reliable respiration and functional responses in mouse and rat islets.

This study shows that NCLX regulates autophagy via calcium signaling, with NCLX knockdown impairing basal and starvation-induced autophagy.

This study shows that NCLX in astrocytes affects glycolysis and cognitive performance, with different impacts based on cell type.

This study shows that adiponectin protects beta-cells from obesity-induced damage and restores insulin secretion by reversing mitochondrial dysfunction and oxidative phosphorylation impairment.

This study quantifies how different calcium concentrations affect mitochondrial respiration in mouse liver mitochondria and hepatocytes, finding an optimal range for oxidative phosphorylation.

This study investigates how caloric restriction affects mitochondrial function in rat kidneys, finding increased calcium uptake and MICU2 loss, contrasting with effects in brain and liver.

This study shows calorie restriction prevents cardiac hypertrophy-induced lipidomic changes, mitochondrial dysfunction, and oxidative stress in vivo.

This study shows that palmitate overload increases glycolysis and causes mitochondrial redox imbalance early in lipotoxicity, without affecting oxygen consumption.

This study examines how short-term caloric restriction affects mitochondrial function in cardiac and skeletal muscle, finding tissue-specific changes in bioenergetics but not in calcium handling or mPT susceptibility.

This study shows endurance exercise enhances muscle stem cell self-renewal by inhibiting mitochondrial oxygen consumption, improving muscle regeneration and reducing inflammation.

This study shows that mitochondrial morphology affects Ca2+ uptake and cellular Ca2+ homeostasis by altering mitochondrial fusion and fission dynamics.