H. Teotonio

Phenotypic stasis with genetic divergence

The paper evolves Caenorhabditis elegans populations for 240 generations and finds phenotypic stasis in locomotion behavior despite genetic divergence.

Variation in mutational (co)variances

The paper estimates the M matrix for locomotion traits in two C. elegans genotypes and finds similar mutational variances but differences from a lab-adapted G matrix due to linkage disequilibrium.

Selection and the direction of phenotypic evolution

The paper shows ancestral phenotypic plasticity in C. elegans does not align with genetic variance, but selection can predict the direction of phenotypic divergence.

The relative strength of selection on modifiers of genetic architecture under migration load

The paper models selection on genetic architecture modifiers under migration load, finding stronger selection for epistasis and dominance modifiers than for recombination reduction.

A single nucleotide change underlies the genetic assimilation of a plastic trait

The paper identifies a single amino acid change in kcnl-1 that causes constitutive matricidal hatching in C. elegans, demonstrating genetic assimilation of an environmentally sensitive trait.

Testing the adaptive value of sporulation in budding yeast using experimental evolution

This study uses experimental evolution to test how sporulation in budding yeast is influenced by exposure to insect vectors, finding that domesticated strains show reduced sporulation and altered response timing.

Selection and drift determine phenotypic stasis despite genetic divergence

The paper shows phenotypic stasis in C. elegans despite genetic divergence, due to stabilizing and disruptive selection, with genetic variance-covariance structure changes explained by selection and drift.

Gene-level quantitative trait mapping in an expanded C. elegans multiparent experimental evolution panel

The paper expands the CeMEE panel, reports updated QTL mapping results, and finds that additive QTL explain 3% of trait variance with >80% power.

How differing modes of transgenerational inheritance affect population viability in fluctuating environments

The paper analyzes transgenerational inheritance modes in C. elegans under fluctuating oxygen levels, finding that epigenetic memory with imperfect transmission better explains population growth dynamics than phenotypic plasticity.

Slower environmental change hinders adaptation from standing genetic variation

This study shows that slower environmental change reduces adaptation from standing genetic variation in C. elegans by increasing population bottlenecks and reducing fixation of beneficial genotypes.

Polygenicity And Epistasis Underlie Fitness-Proximal Traits In The Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel

The paper uses the CeMEE panel to study the genetic basis of fertility and body size in C. elegans, finding that epistasis, not common additive alleles, explains significant trait variance.