S. Dey

AP2/ERF transcription factors enriched in the drought-response transcriptome of the Thar desert tree Prosopis cineraria show higher copy number and greater DNA-binding affinity than orthologs in drought-sensitive species

This study identifies AP2/ERF transcription factors as key to drought tolerance in Prosopis cineraria, showing higher copy numbers and DNA-binding affinity compared to drought-sensitive species.

Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy

This study shows that FBXO31-mediated γH2AX foci formation is essential for DNA repair pathways and that its loss sensitizes breast cancer to chemotherapy.

Direct and Indirect Salt Effects on Homotypic Phase Separation

This study investigates how salt affects the phase separation of hnRNPA1's low-complexity domain, finding that NaCl promotes phase separation by neutralizing charge and bridging protein chains.

Temperature-Dependent Fold-Switching Mechanism of the Circadian Clock Protein KaiB

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic

The paper develops a thermo-amplifier circuit in probiotic E. coli to control the release of darobactin, a peptide antibiotic, at 40°C while maintaining low leakiness at 37°C.

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

Cooperation Destabilizes Communities, but Competition Pays the Price

The paper studies how external perturbations affect ecological communities, finding that cooperative interactions increase extinction risk but leave some species intact, leading to a community with more cooperation.

Kinetics and dynamics of single-molecule multivalent interactions revealed by plasmon-enhanced fluorescence

This study uses plasmon-enhanced fluorescence to analyze the kinetics and dynamics of single-molecule multivalent interactions, revealing how spacer length and flexibility affect binding strength and dynamics.

Mice Models to Bioinformatics Methods Led to the Discovery of Antidiabetic Compounds in the F. racemosa Plant Extracts

The paper uses animal models and in silico experiments to identify antidiabetic compounds in Ficus racemosa extracts, finding four compounds with potential therapeutic effects.

Population size shapes trade-off dilution and adaptation to a marginal niche unconstrained by sympatric habitual conditions

This study shows larger populations of E. coli adapt better to both habitual and marginal niches, with habitual niche composition not constraining adaptation to marginal niches.

In vivo and in silico experiment on Mitragyna speciosa offers new insight of antidiabetic potentials

This study investigates the anti-diabetic potential of Mitragyna speciosa using in vivo and in silico methods, finding that extracts reduce blood glucose levels and four compounds bind effectively to the DPP4 receptor.

Selection for dispersal under larval malnutrition results in a non-monotonic kernel in Drosophila melanogaster

This study shows that selecting Drosophila melanogaster for dispersal under larval malnutrition results in a non-monotonic dispersal kernel with peak frequencies at intermediate distances.

A resource-based mechanistic framework for castration-resistant prostate cancer (CRPC)

This paper develops a resource-based mechanistic model of castration-resistant prostate cancer (CRPC) to understand how cell competition and resource dynamics influence tumor relapse.

KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons

This study shows KLP-7/Kinesin-13 is essential for axon-dendrite compartmentalization by regulating microtubule dynamics and preventing mislocalization of axonal proteins in C. elegans neurons.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence

This study shows hyperglycemia increases TERF2IP and TRF2 via H3K4me3-p65 axis, driving endothelial senescence through p53 and p21 upregulation.

UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

This study uses scRNA-seq and spatial transcriptomics to show UVB exposure alters immune-stromal interactions and T cell recruitment during cryptic Leishmania donovani infection.

Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity

This study investigates how cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity in a pressure-overload heart failure model.

Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

Plasmonic Stimulation of Gold Nanorods for the Photothermal Control of Engineered Living Materials

This paper demonstrates the use of plasmonic gold nanorods to control engineered living materials via infrared photothermal heating, enabling spatially controlled stimulation of thermoresponsive bacteria.

Why Does Synergistic Activation of WASP, but Not N-WASP, by Cdc42 and PIP2 Require Cdc42 Prenylation?

The paper uses molecular dynamics simulations to show that Cdc42 prenylation is required for synergistic activation of WASP with PIP2, but not N-WASP.

Membrane Tethering of SepF, a Membrane Anchor for the Mycobacterium tuberculosis Z-ring

This study identifies how SepF, a membrane anchor in Mtb, tethers to acidic membranes through specific residues, stabilizing Z-ring proximity for recruitment of FtsW and CrgA.

Bacteria evolve macroscopic multicellularity via the canalization of phenotypically plastic cell clustering

This study shows that bacteria can evolve macroscopic multicellularity through canalization of phenotypically plastic cell clustering, with mutations in cell wall genes enabling stable cluster formation.

An Arg/Ala-Rich Helix in the N-Terminal Region of M. tuberculosis FtsQ Anchors FtsZ to Membranes

This paper identifies an Arg/Ala-rich helix in M. tuberculosis FtsQ that anchors FtsZ to membranes, influencing Z-ring formation and curvature.

Coupling of protein condensates to ordered lipid domains determines functional membrane organization

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

Ferric reductase-related proteins mediate fungal heme acquisition

The paper identifies Frp1 and Frp2 as proteins required for heme utilization in Candida albicans and shows they form a functional complex with CFEM hemophores for extracellular heme uptake.

Modelling spatially autocorrelated detection probabilities in spatial capture-recapture using random effects

This paper introduces and evaluates three Bayesian spatial capture-recapture models to account for spatial heterogeneity in detection probabilities, finding that spatially autocorrelated random effects provide the least biased population size estimates.

A cobB like protein in Oryza sativa indica regulates the mitochondrial machinery under stress conditions

This paper identifies a new class III sirtuin in Oryza sativa indica that regulates mitochondrial and nuclear processes under stress conditions.

Dynamic analysis of sequestration-based feedbacks in cellular and biomolecular circuits

The paper analyzes sequestration-based feedback mechanisms in biological systems, showing how degradation enhances robustness to disturbances and how stochastic fluctuations are influenced by feedback strength.