Disease context dictates the cellular targets of IL-17 in inflammatory skin disease
Kellen J. Cavagnero, Fengwu Li, Haley Jo, Carlos Aguilera, Jennifer P. Fox, Joseph Kirma, Rachael Wasikowski, Joanne Michelle Kahlenberg, Lam C. Tsoi, Johann Eli Gudjonsson, Richard L. Gallo
This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.
Journal of Investigative Dermatology · Jul 1, 2026Peer-reviewedImmunology