Joanne Michelle Kahlenberg

This study identifies CD38 as a regulator of interferon responses in juvenile dermatomyositis and suggests its inhibition as a potential therapeutic strategy.

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

The paper introduces IGNITE, a framework that combines genetic data with functional genomics to prioritize immune drug targets, showing improved performance over genetic methods alone.

This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.

This study identifies molecular changes in perivascular adipose tissue in lupus mice, showing mitochondrial dysfunction, immune activation, and impaired adipogenic capacity.

This study compares dermatomyositis and lupus skin lesions using single-cell RNA-sequencing to identify inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis.

The paper identifies TWEAK-IL-13 signaling as a driver of paradoxical skin reactions following anti-TNF, IL-17, or IL-23 therapy.

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.

This study identifies Als4112 as critical for Candida auris skin colonization and explores collagen coatings to prevent adherence.

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

This study conducts a multi-ancestry GWAS meta-analysis of 56,146 AD cases and 602,280 controls, identifying 101 genomic loci, 15 novel to AD or eczema, and linking them to AD pathophysiology through functional analyses.