This study quantifies cancer stemness in prostate cancer across progression stages, showing its association with therapy resistance, poor survival, and lineage plasticity.

Molecular Cancer · Oct 27, 2026Peer-reviewedCancer Biology

The Two-Component System CrdRS Mediates Sub-inhibitory Antibiotic-Induced Biofilm Formation in Helicobacter pylori via Bidirectional Regulation of Transporters PlpA and GlnP

Wenxin Zhang, Lu Zhang, Yanlin Sun, Mingzhong Zhao, 徐书景, Han Yu, Wenjing Wang, Jinmeng Liu, Wenyue Ma, Xiaoyu Wang, Ziyan Zhang, Yundong Sun

This study identifies the CrdRS two-component system as a key regulator of antibiotic-induced biofilm formation in H. pylori through bidirectional control of transporters PlpA and GlnP.

Antimicrobial Agents and Chemotherapy · Oct 5, 2026Peer-reviewedMicrobiology

Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study validate BCL-2 as a target across heterogeneous CRPC subtypes

Anmbreen Jamroze, Xiaozhuo Liu, Surui Hou, Wen Jess Li, Han Yu, Amanda Tracz, Justine J. Jacobi, Qiuhui Li, Kent L. Nastiuk, Xin Chen, Jiaoti Huang, Kevin Lin, Mingyu Liu, Changmeng Cai, Yue Lu, , Dean G. Tang

This study validates BCL-2 as a therapeutic target in CRPC by showing its upregulation under AR inhibition and demonstrating efficacy of BCL-2 inhibitors in preclinical and clinical models.

Signal Transduction and Targeted Therapy · May 1, 2026Peer-reviewedCancer Biology

DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Julien Boussard, Charlie Windolf, Cole Hurwitz, Hyun Dong Lee, Han Yu, Olivier Winter, Liam Paninski

DARTsort improves spike sorting by incorporating drift tracking, outperforming Kilosort 2.5 on simulated data with drift and noise.

bioRxiv · Aug 11, 2023 · PreprintNeuroscience