Xiaoyu Wang

Erythrocyte extravasation drives ferroptosis and inflammatory amplification in eccentric contraction-induced skeletal muscle injury via the heme-HO-1-iron axis

This study investigates how erythrocyte extravasation contributes to skeletal muscle injury via the heme-HO-1-iron axis, linking it to ferroptosis and inflammation.

Melanoma germline genetics: immune, cancer driver, and Wnt signaling genes

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

The Two-Component System CrdRS Mediates Sub-inhibitory Antibiotic-Induced Biofilm Formation in Helicobacter pylori via Bidirectional Regulation of Transporters PlpA and GlnP

This study identifies the CrdRS two-component system as a key regulator of antibiotic-induced biofilm formation in H. pylori through bidirectional control of transporters PlpA and GlnP.

Flytrap-Inspired Mesh-Trap Bioelectronics for Full Spherical Electrophysiological Interrogation of 3D Tissues

This paper introduces a bioelectronic mesh system for comprehensive electrophysiological monitoring of 3D tissues and assembloids, enabling long-term stable recordings and high-throughput analysis.

Genetically Engineered Biomimetic Nanozymes Reprogram Immune Niches to Intercept Colitis-Carcinoma Transition

This paper develops genetically engineered nanozymes that target immune niches to prevent colitis-associated colorectal cancer by reducing oxidative stress and immune cell infiltration.

A spatiotemporal immune atlas of subarachnoid hemorrhage from single-cell and spatial transcriptomics

This paper constructs a spatiotemporal immune atlas of subarachnoid hemorrhage using single-cell and spatial transcriptomics to identify immune cell subsets and their dynamics.

HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation

The paper investigates how HEXIM1 autoinhibition is overcome by 7SK RNA binding to enable P-TEFb inactivation, revealing structural and functional mechanisms of 7SK RNP assembly.

Identifying High-Dimensional Genomic Factors Modulating Biological Networks Across Multi-Omics Data

GFBioNet identifies genomic factors modulating trait-trait relationships in multi-omics data, revealing host genetics, microbial taxa, and mutations affecting biological networks.

KcatNet: A Geometric Deep Learning Framework for Genome-Wide Prediction of Enzyme Catalytic Efficiency

KcatNet predicts enzyme catalytic efficiency using geometric deep learning, outperforming existing methods and providing insights into enzyme-substrate interactions.

Atom-economic enantioselective photoenzymatic radical hydroalkylation via single-electron oxidation of carbanions

This paper introduces a photoenzymatic system for enantioselective hydroalkylation of C(sp3)-H bonds using a flavin-dependent ene-reductase and fluorescein, achieving atom-economic and enantiodivergent reactions.

Computational Analysis of Zn2+ Mediated Non-Competitive Inhibition to Caspase-3

This study uses computational methods to analyze Zn2+-mediated non-competitive inhibition of caspase-3, revealing atomic-level insights into its mechanism and potential therapeutic applications.

Annihilation of Methicillin-resistant Staphylococcus aureus via Photobleaching of Staphyloxanthin

This study demonstrates a drug-free method to eliminate MRSA by photobleaching staphyloxanthin, which sensitizes bacteria to reactive oxygen species.