Xin Chen

Intrinsic fluctuations modulate thalamic gating during the emergence of human conscious perception

This study shows that intrinsic thalamic fluctuations before stimulus onset modulate conscious perception by compensating for stimulus strength and enabling efficient information processing.

Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

A pretrained unified model enables cellular functional profile prediction and multi-objective virtual drug screening

InsilicoCell predicts cellular functional profiles and enables multi-objective virtual drug screening by integrating diverse molecular data and tasks.

CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design

CENO is a long-context generative model for genomic sequence understanding and design, showing improved variant prediction and regulatory sequence generation across species.

Prenatal cannabis exposure affects human fetal neurodevelopment: anintegrated multi-omics study

This study investigates the molecular effects of prenatal cannabis exposure on human fetal brains, finding significant disruptions in male second trimester brains linked to neurodevelopmental disorders.

A human intracranial map of consciousness returning from anesthesia

This study maps the electrophysiological changes in the human brain as consciousness returns from anesthesia, identifying key neural dynamics associated with the transition from unconsciousness to wakefulness.

Polynomial Trajectory Compression for Protein Language Model Embeddings

This paper introduces a method to compress protein language model embeddings using polynomial trajectories and PCA, achieving efficient storage and reconstruction without loss of downstream task performance.

NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism

This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.

Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study validate BCL-2 as a target across heterogeneous CRPC subtypes

This study validates BCL-2 as a therapeutic target in CRPC by showing its upregulation under AR inhibition and demonstrating efficacy of BCL-2 inhibitors in preclinical and clinical models.

Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis.

This study identifies methionine metabolism and the NOP2 methyltransferase as critical for MYC-driven liver tumorigenesis, suggesting NOP2 as a potential therapeutic target.

Genomic Surveillance Reveals Global Spread of Macrolide-Resistant Bordetella pertussis Linked to Vaccine Changes

The paper analyzes genomic data from Bordetella pertussis isolates to show increased macrolide resistance and spread of a specific lineage linked to vaccine changes.

A benchmarking study of copy number variation inference methods using single-cell RNA-sequencing data

This study benchmarks five scCNV inference methods across multiple scRNA-seq platforms and mixed samples, finding variations in performance based on data characteristics and batch effects.

Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease

This paper introduces a living glue made of engineered bacteria that detects and treats inflammatory bowel disease in mice by monitoring bleeding and producing therapeutic proteins.

Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

Unraveling fungal endolysosomal network as a potential target for effective disease control

This study identifies key components of the fungal endolysosomal network and shows that targeting them reduces fungal pathogenicity.

Distinct 'pattern of autofluorescence' of acute ischemic stroke patients' skin and fingernails: A novel diagnostic biomarker for acute ischemic stroke

This study identifies a novel diagnostic biomarker for acute ischemic stroke using green autofluorescence patterns in skin and fingernails, showing high accuracy in differentiating AIS patients from healthy and non-AIS groups.

Establishing reference samples for detection of somatic mutations and germline variants with NGS technologies

The paper establishes reference samples with high-coverage whole-genome sequencing to create truth sets for somatic mutation and germline variant detection using NGS technologies.

ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathways

This study shows ASXL3 regulates cortical neuron fate through extrinsic signaling and epigenetic pathways, linking it to ASD risk.

ŌvSim: a Simulation of the Population Dynamics of Mammalian Ovarian Follicles

The paper introduces ŌvSim, a Markov chain model simulating mouse ovarian follicle dynamics, showing it approximates biological measurements like follicle counts.

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

The paper identifies a novel dominant rice male sterility mutant, OsDMS-1, and reports three loci controlling its sterility, conflicting with classical genetic analysis.