Latent Transforming Growth Factor Binding Protein-2 promotes microfibrillar TGF-β bioavailability to drive pathologic fibrosis in remote regions of infarcted hearts
Fahad Ehsan, Michelle Di Paola, Micael Dewar, Hangjun Zhang, Uros Kuzmanov, Yu-Qing Zhou, Cristine J Reitz, Haisam Shah, Tao Wang, Jingzhi Liu, Aliya Izumi, Rundong Hu, Joanna Hendy, Fareshteh Sadat Younesi, Mark K. Friedberg, , Scott P Heximer
This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.
bioRxiv · Nov 3, 2026 · PreprintPhysiology