Structural dynamics insights into principles underlying the fitness of new broadly potent AAVs
Molly E. Johnson, Bilge Esin Öztürk, Thomas H. Tugwell, Maryl Lambros, Haley N. Janowitz, Keevon Flohr, Morgan Sedorovitz, Laura Campello, J Hartung, Brett C. Hogle, Megan E. Gillespie, Hannah Schriever, Hamzah Aweidah, Janis Koester, Inga Clausen, , Leah C. Byrne
The paper develops a new AAV engineering workflow, scAAVengr-Hunt, to create potent vectors and identifies a structural mechanism underlying their broad species and tissue potency.
bioRxiv · May 17, 2026 · PreprintBioengineering