Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior
Hanna Böke, Hannah Schulte, Maria Worm, Julia Bihorac, Brix Mücher, Martin Hadamitzky, Ida Siveke, Stefan Herlitze, Katharina Spoida
This study shows that Opn7b, a constitutively active GPCR, reduces cFos expression and modulates avoidance behavior in mice by activating the Gi/o pathway in specific brain regions.
Frontiers in Behavioral Neuroscience · Jun 5, 2025Peer-reviewedNeuroscience