IL-36γ Drives Th9 cell Differentiation via IκBζ to Sustain Antitumor Immunity
Qitai Zhu, Yu Chen, Jianling Gao, Peijun Tang, Zhenghao Ma, Xinying Li, Haolin Jiang, Ziyi Huang, Yachen Zang, Xin Zhao, Ji Zhang, Xuefeng Wang
This study identifies IL-36γ as a cytokine that synergizes with TGF-β to drive Th9 cell differentiation via IκBζ, enhancing antitumor efficacy in adoptive cell therapy.
bioRxiv · May 4, 2026 · PreprintImmunology