Xin Zhao

DiffGSP: reversing mRNA diffusion to unlock high-fidelity spatial transcriptomics

DiffGSP reverses mRNA diffusion to improve spatial transcriptomics fidelity, revealing fine anatomical structures and spatial gene modules in various tissues.

Primitive GLMY Homology: An Algebraic Topology Approach for the Quantitative Characterization of Graph Pangenomes toward Population Genetic Analysis

This paper introduces Primitive GLMY Homology to quantitatively analyze graph pangenomes and applies it to population genetic analysis in yeast.

Using Natural Vector Method for Population Genomic Analysis on Human Mitochondrial Genome Data

This study applies a modified natural vector method to mitochondrial genome data from the 1000 Genomes Project to evaluate population genetic characteristics beyond pairwise comparisons.

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

IL-36γ Drives Th9 cell Differentiation via IκBζ to Sustain Antitumor Immunity

This study identifies IL-36γ as a cytokine that synergizes with TGF-β to drive Th9 cell differentiation via IκBζ, enhancing antitumor efficacy in adoptive cell therapy.

Identification of a new ORF3a-E fusion subgenomic RNA of SARS-CoV-2 and its biological features in the infection process

The paper identifies a new SARS-CoV-2 subgenomic RNA, ORF3a-E-sgRNA, which enhances viral replication and immune evasion by promoting translation and host protein interactions.

Childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic risk for depression

The paper examines how childhood urbanization affects prefrontal cortical responses to trait anxiety and interacts with polygenic depression risk in a genetically homogeneous population.

Bats adjust temporal features of echolocation calls but not those of communication calls in response to traffic noise

This study shows that bats adjust echolocation call timing features but not communication calls when exposed to traffic noise, challenging the acoustic masking hypothesis.