Yu Chen

U-Chrom: a unified framework for single-cell and spatial 3D genome data

U-Chrom provides a unified framework for analyzing single-cell and spatial 3D genome data, showing consistent cell-type differences across assays.

CD19 CAR Engineered T Regulatory Cells Promote Durable Immune Tolerance in Experimental Systemic Lupus Erythematosus

This study shows that CD19 CAR-engineered regulatory T cells reduce B cell numbers, inflammation, and autoantibodies in lupus models, promoting long-term immune tolerance.

LIFU-Responsive Nanocomplexes Deliver PDGF-BB mRNA for Plaques Stabilization via Neovascularization Modulation

This study delivers PDGF-BB mRNA using LIFU-responsive nanocomplexes to stabilize atherosclerotic plaques by enhancing neovascularization and fibrous cap thickness.

ALPINE: A Scalable Pipeline for Comprehensive Classification of Gene-Editing Outcomes from Long-Read Amplicon Sequencing

ALPINE classifies gene-editing outcomes from long-read amplicon sequencing into 10+ categories, including DNA repair vector integrations, with high accuracy.

Stage-adaptive integration of polydopamine promotes hPSC-derived alveolar organoids differentiation and maturation

This study shows that stage-adaptive integration of polydopamine coatings and nanoparticles enhances the maturation and secretory function of hPSC-derived alveolar organoids.

IL-36γ Drives Th9 cell Differentiation via IκBζ to Sustain Antitumor Immunity

This study identifies IL-36γ as a cytokine that synergizes with TGF-β to drive Th9 cell differentiation via IκBζ, enhancing antitumor efficacy in adoptive cell therapy.

U-Probe: universal agentic probe design for imaging-based spatial-omics

U-Probe is a universal probe design platform that enables agentic, AI-assisted creation of FISH probes for spatial-omics applications, validated across multiple scenarios.

Engineered Promoter System Enables High-efficiency Transgenic CRISPR Editing in Malaria Transmitting Mosquito Anopheles sinensis

The paper identifies effective promoters for CRISPR editing in Anopheles sinensis, achieving high editing efficiency in transgenic mosquitoes.

The Molecular Landscape of Cellular Metal Ion Biology

The paper quantifies yeast cell responses to varying metal ions, revealing widespread proteomic and genetic impacts and common metal responsiveness properties.

Brain eQTLs of European, African American, and Asian ancestry improve interpretation of schizophrenia GWAS

This study identifies population-specific eQTLs in brain tissues from European, African American, and Asian ancestry individuals, revealing new schizophrenia risk genes and variants missed in European-only datasets.

Spatially resolved molecular and cellular atlas of the mouse brain

The paper creates a high-resolution spatial transcriptomic atlas of the mouse brain using snRNA-seq and Stereo-seq, identifying new cell clusters, region-specific genes, and transcription factor regulons.

Preliminary Study of the Potential Mechanism of CTSD in the Aging Process of Sepiella japonica: Fundamental Function Analysis

This study investigates the role of the CTSD gene in the aging process of Sepiella japonica by analyzing its expression and functional properties.

Bacillus cereus HS24 Suppresses Conidia Germination of Magnaporthe oryzae by Inhibiting the Ca2+ Signaling Pathway

This study shows that Bacillus cereus HS24 inhibits conidial germination of Magnaporthe oryzae by suppressing the Ca2+ signaling pathway, offering potential as a bio-control agent for rice blast.

Arabidopsis ATHB17 coordinates nuclear and plastidic photosynthesis gene expression in response to abiotic stress

This study identifies ATHB17 as a coordinator of nuclear and plastid gene expression under abiotic stress, enhancing stress tolerance through regulation of photosynthesis-related genes.