BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering
Shubing Wang, Yan-Ruide Li, Qian Wang, Youcheng Yang, Xinyuan Shen, Haoran Li, Haochen Nan, Z J Chen, Yichen Zhu, B Y Zhang, Haoyan Ding, Jennifer Soto, Soomin Park, Yi Zheng, Xiangliang Huang, Debiao Li
A provenance-tracked multi-agent system curated 57 CAR-T patient scRNA-seq studies, generated reviewable hypotheses, and prioritized KLRC1/NKG2A, whose blockade improved CD8+ CAR-T antitumour activity in a Raji xenograft model.
bioRxiv · Jul 28, 2026 · PreprintBioengineering✦ In-depth digest