Qian Wang

Stable large-scale network architecture and structured individual variability in the awake mouse brain

The paper introduces the Awake Mouse Connectome Project (AMCP), a dataset of 212 awake mice, and presents functional network atlases and analysis tools for studying brain connectivity and variability.

Mapping the Fragment-Binding Landscape of SARS-CoV-2 nsp14 for Antiviral Drug Discovery

The paper maps the fragment-binding landscape of SARS-CoV-2 nsp14, identifies promising sites for antiviral drug development, and provides a prioritized resource for future inhibitors.

Immune Reconstitution and Antigenic Exposure History Shape Virus-Specific Humoral Immunity in People with HIV

The paper examines how immune reconstitution and antigenic exposure history influence virus-specific humoral immunity in HIV-treated individuals, finding varied relationships across different viruses.

C1Q-associated adaptive myeloid remodelling accompanies early response to BCMA CAR-T therapy in multiple myeloma

In a ten-patient multiple myeloma reanalysis, myeloid pseudobulk from day-30 BCMA CAR-T responders showed C1Q enrichment with interferon-γ signalling, not cholesterol efflux; patient-level composite scores stayed exploratory.

BioPathfinder: Evidence-guided multi-agent platform enables hypothesis discovery for CAR-T engineering

A provenance-tracked multi-agent system curated 57 CAR-T patient scRNA-seq studies, generated reviewable hypotheses, and prioritized KLRC1/NKG2A, whose blockade improved CD8+ CAR-T antitumour activity in a Raji xenograft model.

Therapeutic targeting of MYC- and MYCN-driven medulloblastoma with a novel MYC degrader molecule

This study identifies UNSW-SC-22 as a novel MYC/MYCN-targeting molecule that crosses the blood-brain barrier and shows potent preclinical efficacy in medulloblastoma.

Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

The paper identifies distinct CD8+ T-cell types associated with mild versus severe COVID-19 in unvaccinated HLA-A2+ patients, showing protective immunity correlates with specific cell subsets.

Functional Landscape of Motifs within the Sarbecovirus Spike Cytoplasmic Tail

This study identifies functional motifs in the Sarbecovirus spike cytoplasmic tail that regulate viral infectivity and assembly, with implications for vaccine development.

IFITM1 inhibits Henipavirus membrane fusion by trapping ephrinB2 receptors in fusion-unfavorable membrane nanodomains.

This paper shows IFITM1 inhibits henipavirus entry by sequestering ephrinB2 in membrane domains that hinder virus-cell fusion.

Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

Hemodynamic phenotypes linked to high-altitude subclinical organ damage

This study identifies three distinct hemodynamic phenotypes in high-altitude dwellers and links them to subclinical organ damage.

Antibody Responses Against Coronaviruses in the Wuhan Population

The paper assesses neutralizing antibody responses to multiple coronaviruses in Wuhan population samples before and after the pandemic, finding enhanced cross-neutralizing activity against sarbecoviruses.

Tryptophan Chemistry Driven by a Widespread Cytochrome P422 Enzyme Family

The paper identifies a widespread cytochrome P422 enzyme family that performs four novel tryptophan transformations, revealing new enzymatic capabilities and introducing a computational tool for HBP discovery.

Dopaminergic inhibition of the inwardly rectifying potassium current in direct pathway medium spiny neurons in normal and parkinsonian striatum

The paper investigates how dopamine regulates inwardly rectifying potassium currents in medium spiny neurons in normal and parkinsonian striatum, showing dopamine enhances neuronal excitability through Kir inhibition.

Saccades orchestrate intraocular glucose to shape visual responses in birds

This study shows that oscillatory saccades in pigeons regulate intraocular glucose levels, linking eye movements to metabolic dynamics and visual processing.

Strigolactone mediates moso bamboo root response to phosphate stress

This study investigates how strigolactone regulates moso bamboo root responses to phosphate stress by analyzing gene expression and hormone effects under different Pi conditions.

Periventricular nodular heterotopia is functionally coupled with the neocortex during resting and task states

This study shows that PVNH tissue is functionally coupled with the neocortex during resting and task states, indicating integration into cortical circuits.

Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development

The paper identifies the functional roles of NG2 and A2B5 in human oligodendrocyte progenitor cell development and suggests mid-stage cells are better for treating demyelinating diseases.

Circular RNA as a potential biomarker for forensic age prediction using multiple machine learning models: A preliminary study

This study explores circRNAs as age prediction biomarkers using machine learning models in forensic contexts, identifying 7 circRNAs with high predictive accuracy.

The efficiency for recombineering is dependent on the source of the phage recombinase function unit

The paper investigates PRFU efficiency in recombineering, finding that source, not species distance, determines efficiency in Corynebacterium glutamicum.

New logic facilitated identification of novel phage recombinase function units

The paper identifies 59 unique PRFUs in Corynebacterium species, showing their strain-related occurrence and effectiveness in recombineering.

Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure

This study shows that PKD2 channels in arterial smooth muscle cells regulate blood pressure and that their removal lowers blood pressure and prevents hypertension-related arterial remodeling.

Genetic basis underlying connection between hyperglycemia and dyslipidemia in Apoe-deficient mice

The paper identifies genetic connections between hyperglycemia and dyslipidemia in Apoe-deficient mice by analyzing QTLs and their correlations with lipid and glucose levels.