Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice
Daria Timonina, Genesis Vega Hormazabal, Indra Heckenbach, Edward Anderton, Lauren Haky, Ariel Floro, Rebeccah R. Riley, Ryan Kwok, Stella Breslin, Harris Ingle, Ritesh Tiwari, Olga Bielska, Morten Scheibye‐Knudsen, Herbert G. Kasler, Judith Campisi, , Eric M. Verdin
This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.
bioRxiv · Oct 17, 2023 · PreprintMolecular Biology