ImmunologybioRxivPreprint
Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses
Ariel Floro, Ritesh Tiwari, Mitsunori Nomura…·Eric M. Verdin
DOI 10.64898/2026.04.20.718782
Author
Ryan Kwok
Buck Institute for Research on AgingORCID 0000-0002-1850-6611Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 44 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- ImmunologyAging CellPeer-reviewed
Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells
Hiroyuki Matsui, Marlene Cervantes, Mir Mubashir Khalid…·Eric Verdin
The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.
1 citation - ImmunologybioRxivPreprint
Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State
Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui…·Eric M. Verdin
The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.
1 citation - Molecular BiologyNature MetabolismPeer-reviewed
Regulation of urea cycle by reversible high stoichiometry lysine succinylation
Ran Zhang, Jingqi Fang, Xueshu Xie…·Eric M. Verdin
This study identifies high stoichiometry lysine succinylation sites in mouse liver, showing their functional role in urea cycle regulation and ammonia metabolism through SIRT5.
28 citationstop 2% - Molecular BiologybioRxivPreprint
Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice
Daria Timonina, Genesis Vega Hormazabal, Indra Heckenbach…·Eric M. Verdin
This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.
DOI 10.1101/2023.10.17.562803